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Meischer
Researched the molecule nuclein. He saw metabolic changes in salmon when they spawn. He believed that proteins were the molecules of heredity. He paved the path for the discoveries concerning DNA that followed. -
Chargaff
Chargaff observed that the amount of thymine bases was equal to those of adenine bases, vice versa, and the number of cytosine bases was equal to those of guanine bases and vice versa. This is known as Chargaff’s rule. -
Franklin
Franklin gave Watson and Crick two High-Resolution photos of Crystallized DNA, and that helped them solve the puzzle of DNA -
Hershey and Chase
Proved that DNA, not protein, is the source of genetic material -
Watson and Crick (continued)
Watson and Crick’s work was published in Nature. Later they got a Nobel Peace Prize for their discoveries concerning the molecular structure of nucleic acids and its significance for information transfer in living material. -
Watson and Crick
Watson found DNA while looking at x-ray photos. Then he started to study protein x-ray diffraction. He and Francis Crick developed a three-stranded helix. In the Three stranded helix, the base rings were located on the outside of the molecule, and the phosphate groups were found on the inside. The only flaw was that there wasn’t enough space to fit the left over negatively charged phosphates into the DNA without it exploding. -
Meselson and Stahl
Meselson and Stahl cemented the concept of the double helix and how two intertwined strands of a helix could physically code for the material of inheritance.
