-
Meischer
- investigated leukocytes he found on old bandages from a nearby hospital that had different proteins, developing the first sample of isolated DNA
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Chargaff
- Chargaff's rule was obviously established by him, which speaks of complimentary base pairing (a-t, c-g) -
Franklin
- discovered that DNA exists in wetter and drier states, but both have 2 distinct strands (double helix)
- used x ray images and chromatography
- her work led to the Watson and Crick breakthrough to produce the modern model of DNA
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Hershey and Chase
- the Hershey Chase Blender Experiment proved that DNA is actually genetic material, not just protein sequences
- the pair infected the bacterium E. coli with a virus, which damaged and destroyed the cell and showed that it was the virus genetic code that interfered and not just the protein coating
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Watson & Crick
- James Watson and Francis Crick used a template of Pauling's helix, Chargaff's nitrogenous bases, and Franklin's phosphate groups to formulate a double helix model of DNA
- they conducted research in the labs of Cambridge via a trial-and-error method despite having been told to give up
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Meselson and Stahl
- study at their university lab on bacterial cells showed that DNA replication does result in two semi-conservative models, solidifying the preconceived concept of a double helix
-
Works Cited
"Rosalind Franklin: Biography & Discovery of DNA Structure." LiveScience. Purch, n.d. Web. 20 Jan. 2017. http://www.livescience.com/39804-rosalind-franklin.html. Watson and Crick DNA model. Digital image. Nature. N.p., n.d. Web. 20 Jan. 2017. http://www.nature.com/scitable/nated/content/24263/sadava_11_8_large_2.jpg. "Watson and Crick." PBS. PBS, n.d. Web. 20 Jan. 2017. <http://www.pbs.org/wgbh/aso/databank/entries -
Works Cited
Photo 51. Digital image. Public Broadcasting Service. N.p., n.d. Web. 19 Jan. 2017. http://www-tc.pbs.org/wgbh/nova/photo51/images/pict-1951photo51.jpg. "Erwin Chargaff." Biography - Famous Biologists. N.p., n.d. Web. 19 Jan. 2017. http://www.macroevolution.net/erwin-chargaff.html. Chargaff's Rule. Digital image. N.p., n.d. Web. 20 Jan. 2017. http://www.bio.miami.edu/dana/pix/Chargaffs_Rule.jpg. -
Works Cited
"Watson and Crick." PBS. PBS, n.d. Web. 20 Jan. 2017. http://www.pbs.org/wgbh/aso/databank/entries/do53dn.html. Watson and Crick DNA model. Digital image. Nature. N.p., n.d. Web. 20 Jan. 2017. http://www.nature.com/scitable/nated/content/24263/sadava_11_8_large_2.jpg. -
Works Cited
Chargaff DNA Protocol. Digital image. N.p., n.d. Web. 21 Jan. 2017. http://www.howdoweknowit.com/wp-content/uploads/2013/06/MiescherDNAprotocol.jpg.
