- 
  
  Verrazzano, sailing for France discovers New York Harbor
 - 
  
  Frenchman Jacques Cartier navigate the St. Lawrence River names an island along the River Montreal.
 - 
  
  Jamestown is founded on the coast of Virginia by 100 English settlers.
 - 
  
  French explorer, Samuel de Champlain, founds the colony of Quebec.
 - 
  
  Henry Hudson, exploring for the Netherlands, claims land that will become New Netherland
 - 
  
  An epidemic of smallpox, brought by Europeans, kills many Native Americans
 - 
  
  War between the British and French, known as the French & Indian War. The war is fought over disputed land claims in the Ohio Valley.
 - 
  
  King Phillip's War begins in Colonial villages of Massachusetts, between colonists and Native Americans