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The Europeans brought an epidemic of smallpox, which kills many Natives on the New England Coast.
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Verrazzano was sailing for France, but he soon became the first to explore the East coast of the now United States of America.
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A Frenchman, Jacques Cartier, navigates the St Lawrence River and names an island along the River Montreal.
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Over 100 English settlers find Jamestown on the coast of Virginia.
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A French explorer, Samuel de Champlain founded the colony of Quebec.
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While exploring for the Netherlands, Henry Hudson claims land that will become New Netherland.
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The Duke of York drives out the Dutch in New Netherland. He claims the colony for England and renames it New York.
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King Philip's war begins in Massachusetts between colonists and Natives.
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Sieur de la Salle claims the lower Mississippi Valley for France and names it Louisiana.
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A war between the British and the French began over disputed land claims in the Ohio River Valley.
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Pilgrims from England found an English colony in Plymouth, Massachusetts.