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Discovery of nucleic Acids
Isolated the genetic material from white blood cell nuclei. He noted it had a acidic nature and called it nuclein.
Friedrich Miescher (1844 - 1895) -
Levene's Tetranucleotide
It was thought to be organized in tetrads, with four nucleotides per molecule, thus creating a simple structure. But unfortunately Levene was wrong. -
Frederick Griffith
He was a bacteriologist who studied two strains of streptococci that caused pneumonia and was the first to demonstrate bacterial transformation. -
Avery, MacLeod and, McCarty
They explained the results of Frederick Griffith's findings. It was determined that what actually caused the transformation and they transformed it by mixing it with some enzymes. -
Double Helix?
Watson and Crick created the first model of DNA and described it as a double helix structure with sugars and phosphates in the center and nucleobases on the outside, although it turned out to be incorrect. -
Counting nucleobases
He was interested in the percentages of the different nucleobases and noticed something very strange creating chargaff's rules. -
Hersey-chase Experiments
What they did was to use a bacterial cell and then they took bacteriophages labeled in a certain way.
They came to the conclusion that it was the DNA and not the protein that was the genetic material and the protein served as a packaging, basically, to cover it. The genetic material is what infects the bacteria. -
Rosalind Franklin Photo 51
She was an X-ray crystallographer, she took amazing pictures of the B form of DNA, she figured out how to see the wet form, the form that exists in cells.