-
Discovery Of Nucleic Acids
Nucleic acids were discovered in
1868, when twenty-four-year-old Swiss physician Friedrich Miescher isolated a new compound from the nuclei of white blood cells. This compound was neither a protein nor lipid nor a carbohydrate; therefore, it was a novel type of biological molecule. -
Discovery of DNA Components
DNA was discovered in 1869 by Swiss researcher Friedrich Miescher, who was originally trying to study the composition of lymphoid cells (white blood cells). Instead, he isolated a new molecule he called nuclein (DNA with associated proteins) from a cell nucleus. -
Structure of Nucleic Acids
Abstract. In the winter of 1868/9 the young Swiss doctor Friedrich Miescher, working in the laboratory of Felix Hoppe-Seyler at the University of Tübingen, performed experiments on the chemical composition of leukocytes that lead to the discovery of DNA -
Levene`s Tetranucleotide
Levene is known for his tetranucleotide hypothesis which proposed that DNA was made up of equal amounts of adenine, guanine, cytosine, and thymine. Before the later work of Erwin Chargaff, it was widely thought that DNA was organized into repeating tetranucleotides in a way that could not carry genetic information. -
Frederick Griffith
Frederick Griffith, (born October 3, 1877, Eccleston, Lancashire, England—died 1941, London), British bacteriologist whose 1928 experiment with bacterium was the first to reveal the “transforming principle,” which led to the discovery that DNA acts as the carrier of genetic information. -
Oswald Avery
In a very simple experiment, Oswald Avery's group showed that DNA was the "transforming principle." When isolated from one strain of bacteria, DNA was able to transform another strain and confer characteristics onto that second strain. DNA was carrying hereditary information. -
Macly McCarty
They used enzymes to degrade different classes of molecules and proved that DNA was the transforming factor. Their landmark paper was published in 1944. McCarty had been drafted in 1942 and did most of the work in a naval uniform as part of the naval research unit based at Rockefeller Hospital. -
Colin Macleod
How did Colin MacLeod contribute to the understanding of DNA?
Oswald Avery, Colin MacLeod, and Maclyn McCarty showed that *DNA (not proteins) can transform the properties of cells, clarifying the chemical nature of genes
*. Avery, MacLeod and McCarty identified DNA as the "transforming principle" while studying Streptococcus pneumoniae, bacteria that can cause pneumonia. -
Linus Pauling
In the 1950's, Linus Pauling became known as the founder of molecular biology due to his discovery of the spiral structure of proteins (Taton, 1964). Pauling's discoveries contributed to Watson and Crick's breakthrough of the DNA double helix. -
Erwin Chargaff
What did Erwin Chargaff do in 1950?
In 1950, he discovered that the amounts of adenine and thymine in DNA were roughly the same, as were the amounts of cytosine and guanine. This later became known as the first of Chargaff's rules. Honors awarded to him include the Pasteur Medal (1949) and the National Medal of Science (1974) -
Hershy-Chase Experiments
Alfred Hershey and Martha Chase showed that only the DNA of a virus needs to enter a bacterium to infect it. Their experiment provided strong support for the idea that genes are made of DNA. They firmly restated the conclusion that Avery, et al. had more tentatively proposed in 1944. -
James Watson
Suddenly, in the spring of 1953, Watson saw that the essential DNA components—four organic bases—must be linked in definite pairs. This discovery was the key factor that enabled Watson and Crick to formulate a molecular model for DNA—a double helix, which can be likened to a spiraling staircase or a twisting ladder. -
Rosalind Reanklin
Image result for Rosalind Franklin dna
The discovery of the structure of DNA in 1953 was made possible by Dr Rosalind Franklin's X-ray diffraction work at King's. Her creation of the famous Photo 51 demonstrated the** double-helix structure of deoxyribonucleic acid**: the molecule containing the genetic instructions for the development of all living organisms. -
Francis Crick
The discovery in 1953 of the double helix, the twisted-ladder structure of deoxyribonucleic acid (DNA), by James Watson and Francis Crick marked a milestone in the history of science and gave rise to modern molecular biology, which is largely concerned with understanding how genes control the chemical processes within -
Francis Crick
What did Francis Crick discover about DNA?
Image result for Francis Crick dna
The discovery in 1953 of the double helix, the twisted-ladder structure of deoxyribonucleic acid (DNA), by James Watson and Francis Crick marked a milestone in the history of science and gave rise to modern molecular biology, which is largely concerned with understanding how genes control the chemical processes within ... -
Maurice Wilkins
In 1962 Wilkins was awarded the Nobel Prize with Francis Crick and James Watson for his contribution to the elucidation of the structure of DNA. Wilkins had been involved in the formative x-ray diffraction work on DNA and was responsible for showing the*first crystalline symmetrical patterns of DNA*
