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Robert Hooke coined 'cells' , Leeuwenhoek observed first microorganisms
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Period: to
Before DNA
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Gregor mendel discovers simple inheritance laws
predicting trait outcomes -
Lois Pasteur discovers fermentation and Germ theory
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Johann Mieshcer discovered DNA is inheritable
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Thomas Hunt Morgan discovered genes were on chromosomes
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Period: to
DNA science
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Fred Griffith proved that genetic material can move from one bacteria to another
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Alexander Fleming isolated penicillin from fungus
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Chargaff showed that adenine pairs with thymine and cytosine pairs with guanine
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Beadle and Tatum "one gene, one enzyme"
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Avery, McCarty, and McLeod DNA is hereditary
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Hershey and Chase proved viruses replicated as DNA
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Rosalind Franklin established DNA is double helix
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Watson and Crick discovered DNA structure
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Hayes discovered plasmid DNA
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Walter GIlbert discovered gene expression through RNA
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Arber, Nathans, and Smith discovered enzymes that cut DNA
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Khorana, and Nirenberg discovered 64 codons(3 bases of DNA)
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DNA plasmids were isolated and purified by Vinograd
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Madel and Higa first transformation of bacterium Escherichia coli.
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Period: to
Rcombinant DNA Tech
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cloning experiments conducted by boyer and cohen
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genetech was founded
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scientsts met to draw up guidelines for work with recombinant dna
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Sanger and Gilbert found a way to sequence DNA
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Period: to
New tools
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boyer inserted a synthetic insulin gene into e.coli
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Botstein found that you can be identified by DNA
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Louise Joy Brown was born who was made in a petri dish
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Ohio University scientists made trasgenic animals
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The u.s supreme court ruled that genetically altered life forms can be patented
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Eli Lilly Company placed insulin gene in bacteria
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Schell, Chilton , Van Mantagu transformed plants
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Kary Mullins invented PCR to amplify DNA
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Jeffries apllied RFLP in DNA profiling
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An automated fluorescence sequencer was invented
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Fenes were moved into an organism through gene gun
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NIH revised safety guidelines
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Andrew Fire and Craig Mello discovered silencing of genes
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Kohler, Milstein, and Jerne used mab technology
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Maynard Olson Invented expression vectors for proteins
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Ian Wilmut cloned Dolly the sheep
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Ability to look at genes on slide was developed
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Dabiri and Garner made faster DNA sequencer
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Ron Breaker coined term riboswitch for mRNA
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Completion of Human Genome Project