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Colonists form First Continental Congress as Britain closes down Boston harbour and deploys troops in Massachusetts.
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American Revolution: George Washington leads Continental Army to fight against British rule.
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Rebel states form loose confederation after defeating the British at the Battle of Yorktown.
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Founding Fathers draw up new constitution for United States of America. Constitution comes into effect in 1788.
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War of 1812 between the US and Britain, partly over the effects of British restrictions on US trade during the Napoleonic Wars.
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US acquires vast tracts of Mexican territory in wake of Mexican War including California and New Mexico.
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Opponents of slavery, or abolitionists, set up Republican Party.
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Lincoln issues Emancipation Proclamation, declaring slaves in Confederate states to be free.
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US gains Puerto Rico, Guam, the Philippines and Cuba following the Spanish-American war. US annexes Hawaii.
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US intervenes in World War I, but rejects membership of League of Nations in its aftermath.
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More than 13 million people are unemployed after the Wall Street stock market crash of 1929 triggers the Great Depression. President Herbert Hoover rejects direct federal relief.
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Racial segregation in schools becomes unconstitutional; start of campaign of civil disobedience to secure civil rights for Americans of African descent.
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US compels Soviet Union to withdraw nuclear weapons from Cuba in what has become known as the Cuban missile crisis.
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President John F Kennedy assassinated; Lyndon Johnson becomes president.
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Republican Party's Ronald Reagan elected president, and goes on to adopt a tough anti-communist policy abroad and tax-cutting policies at home.
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Democratic Party candidate Bill Clinton elected president.
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11 September - Co-ordinated suicide attacks by al-Qaeda terror group prompts the US to embark on a ''war on terror'' that includes invasions of Afghanistan and Iraq.
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Democratic Senator Barack Obama becomes the first black president of the United States.
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Republican candidate Donald Trump wins presidential election, defeating Democratic candidate Hillary Clinton in one of the biggest political upsets in US history. He is inaugurated in January.
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Joe Biden inaugurated president amid unprecedented security, a week after Trump supporters stormed the Capitol in Washington DC.