Timeline of Major Innovations in the History of Biotechnology

  • Inventors of the Microscope

    Inventors of the Microscope
    Robert Hooke and Anton Van Leeuwenhoek invented the microscope just so they could look at cells and other objects that they couldn't have seen before.
  • Laws of Inheritance of traits

    Laws of Inheritance of traits
    Gregor Mendel discovored the laws of inheritanse of traits by working with pea plants.
  • Making of alcohol to prevent sickness

    Making of alcohol to prevent sickness
    Louis Pasteur invented alcohol to help pervent diseases, infections, and sickness.
  • Finding in white Blood Cells, Nucleic Acid

    Finding in white Blood Cells, Nucleic Acid
    Johann Miescher discovered Nucleic Acid in white blood cells for pus on bandages.
  • The study of Fruit flies

    The study of Fruit flies
    Thomas Hunt Morgan studyed fruit flies and discovered that genes were on chromosomes.
  • The making of Penicillin

    The making of Penicillin
    From a fungus Sir Alexander Fleming isolated Penicillin.
  • Strains of Bacteria

    Strains of Bacteria
    Using mice Fred Griffith proved that genetic material can be moved from one strained of bacteria to another.
  • Numbers of Units in DNA and Cytosine Equaled

    Numbers of Units in DNA and Cytosine Equaled
    In DNA numbers , units of adenine equaled those of thymine and cytosine equaled those of guanine is what Chargaff showed.
  • One gene produces one enzyme

    One gene produces one enzyme
    Beadle and Tatum can up with a rule called the "one gene produces one enzyme" Hypothesis.
  • Blending Experiments

    Blending Experiments
    Hershey and Chase porved viruses replicated using DNA and confirmed the role of DNA as the hereditary materrial by using their famous "blender experiment".
  • X-ray Crystallography

    X-ray Crystallography
    Rosalind Franklin and Maurice Wilkins proved through X-ray crystallography that DNA is indeed a double helix.
  • Structure of DNA

    Structure of DNA
    The structure of DNA was discovered by Watson and Crick.
  • Plasmid in DNA

    Plasmid in DNA
    The circular pieces of DNA found in bacteria was found out to be Plasmid DNA by Hayes.
  • Mechanism of Gene

    Mechanism of Gene
    Walter Gilbert discovered the mechanism of gene expression through his study of messenger RNA
  • Bacterial restriction enzymes cut DNA

    Bacterial restriction enzymes cut DNA
    Bacterial restriction enzymes cut Dna this was discovered by Arber, Nathans, and Smith.
  • Discovering the 64 condons

    Discovering the 64 condons
    The 64 condons ( the triplet code of 3 bases in DNA) for the 20 amino acids making up proteins was discovered by Khorana and Nirenberg.
  • Dna Plamids Isolated

    Dna Plamids Isolated
    Vinograd Purified and isolated DNA Pladmids.
  • 1st Transformation of the bacterium Escherichia coli

    1st Transformation of the bacterium Escherichia coli
    THe first transformation of the bacterium Escherichia coli was responsibly founded by Madel and Higa.
  • Cloning Experiments

    Cloning Experiments
    Boyer and Cohen conducted cloning experiments.
  • Genentech

    Genentech
    The worlds first genetic engineering company, Genentech, was founded.
  • Recombinant DNA

    Recombinant DNA
    Paul Berg, the Key organizer, and 140 other scientists met up to draw guidelines for working with recombinant DNA in microorganisms.
  • Sequence DNA

    Sequence DNA
    Given an unknown piece of DNA, Sanger and Gilbert were able to read the correct order of bases of adenine, cytosine, guanine and thymine and found a way to swquence DNA.
  • Sythetic Insulin Gene

    Sythetic Insulin Gene
    A synthetic insulin gene was inserted into e. coli by Boyer.
  • Restriction Fragment Length Polymorphism (RFLP)

    Restriction Fragment Length Polymorphism (RFLP)
    Restriction Fragment Length Polymorphism (RFLP) that one could be identified by the pattern made of one's DNA through a digest by different enzymes was founded by Botstein.
  • 1st Vitro Fertilization

    1st Vitro Fertilization
    Loise Joy Brown was the frist human baby born from in a vitro ferilization, in which sperm and egg are joined in a petri dish and once the egg is fertilized it gets implanted into a womb.
  • Biotech Companies

    Biotech Companies
    A huge startup for the biotech companies was when the U.S. Superme Court ruled that genetically altered life forms can be patented.
  • 1st Transgenic Animals

    1st Transgenic Animals
    The frist transgenic animals were made at Ohio University by scientists.
  • human insulin gene into bacteria

    human insulin gene into bacteria
    A human Insulin gene was placed inside bacteria by Eli Lilly Company.
  • Agrobacterium- mediated gene transfer

    Agrobacterium- mediated gene transfer
    Schell, Chilton, Van Montagu, Fraley, and Horsch transformed plants with the Agrobacterium-Mediated gene transfer.
  • Polymerase Chain Reaction (PCR)

    Polymerase Chain Reaction (PCR)
    Polymerase Chain Reaction (PCR) was invented to amplify DNA in the laboratory by Kary Mullis.
  • RFLP in DNA

    RFLP in DNA
    Jeffries applied RFLP in DNA profiling to the study of criminal cases.
  • Automated Fluorescence Sequencer

    Automated Fluorescence Sequencer
    Speeding up the labor-intense process an Automated Fluorescence Sequencer was invented.
  • Gene Gun

    Gene Gun
    The use of a gene fun is were genes were moved into an organism.
  • Guidelines for recombinant DNA

    Guidelines for recombinant DNA
    NIH revised safety guidelines for recombinant DNA to include plants with Agrobacterium-Mediated gene transfer.
  • RNA interference

    RNA interference
    RNA inerferenced, silencing of genes, in the worm C. elegans was discovered by Andrew Fire and Criag Mello.
  • Monoclonal antibody (MAb)

    Monoclonal antibody (MAb)
    Monoclonal anitbody (MAb) technology was used by Kohler, Milstein, and Jerne.
  • Yeast Artificial Chromosomes

    Yeast Artificial Chromosomes
    "Yeast artificial chromosomes," or YACs, which are expression vectors for large proteins was invented by Maynard Olson and colleagues at Washington University.
  • Cloning "Dolly" the sheep

    Cloning "Dolly" the sheep
    Dolly the sheep was cloned from an adult cell of a ewe at the Rolin Institute in Scotland. The Person who cloned Dolly was Ian Wilmut.
  • DNA Microarray Technology

    DNA Microarray Technology
    Looking at the expression of all the genes of an organism at one time on a microscope slide or silicon chip, was developed with DNA microarray (DNA chip) technology.
  • Higher tech Automated DNA Sequencer

    Higher tech Automated DNA Sequencer
    What greatly sped up the Human Genome Project was Dabiri and Garer's invention an automated DNA sequencer that had a capability of sequencing 76,800 base pairs per hour, 5 to 30 times faster than existing sequencers.
  • Riboswitch

    Riboswitch
    Ron Breaker coined the term Riboswitch for part of an mRNA molecule that can regulate its own activity and therefore gene expression.
  • Human Genome Project

    Human Genome Project
    The project provided the ability to find genes and gave rise to the sequncing of other genomes , Announcement was made of the completion of the Human Genome Project (initiated in 1990) by Francis Collins and Craig Venter.