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In 1291, was the only remaining Crusader cities, Acre, fell to the Muslim Mamluks. Pl.us that the defeat marked the end of the Crusader States and the Crusades themselves.
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Basically the early renaissance was a cultural, scholarly, and sociopolitical movement which texts and through from classical antiquity.
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That the plague went to Europe in October 1347, when the 12 ships from the Black sea docked at the Sicilian port of the Messina. But a other fact was that will most of them when they got there they died but the other half of them survive.
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It began during 1400s and continued through the 1600s. And the European nations began exploring the world.
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It occurred in 1527 when the Holy Roman Emperor, Charles V, and the city was destroyed most of it.
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It resulted in the creation of a branch of Christianity called Protestantism. Even what happened was many religious groups that separated from the Roman Catholic Church due to differences in doctrine.
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That the Renaissance marked the diffusion of the Italian Renaissance to other parts of Europe.
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The rise of empiricism, new inventions, and new discoveries that questioned the works of ancient philosophers like Aristotle or Galen.