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Leonardo is born on April 15 in the village of Anchiano, near the town of Vinci.
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Leonardo moves to Milan to work in the service of the city's duke, Ludovico Sforza. He gains the title of "painter and engineer of the duke.
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The Last Supper is completed.
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Leonardo becomes a member of the Florence painters' guild.
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Leonardo is accused of sodomy; he is publicly humiliated although the charges are later dropped.
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Leonardo paints the Virgin of the Rocks.
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Leonardo begins work as senior military architect and general engineer for Cesare Borgia, son of Pope Alexander VI.
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Leonardo is commissioned to paint the Mona Lisa.
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The king of France invites Leonardo to come work for him.
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Leonardo dies in France.