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The first settlement of the Mexica.
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By 1250 the Valley of Mexico contained numerous city-states.
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In 1325, the building of Tenochtitlan was put into place. The Aztec god, Huitzlipochtli, is said to have instructed them on where to found this city.
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Itzcoatl ruled and expanded from 1427, up until 1440.
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The Aztecs formed a three-way alliance with the Texcocans and Tacubans. Under the leadership of Itzcoatl they defeated their most powerful rivals, the Tepanec.
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Moctezuma I and Tlacaelel were half brothers who were primary architects of the Aztec empire. Tlacaelel reformed Aztec state and Aztec religion until 1469, while Moctezuma I worked on expansion.
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In 1511-1512 the Aztecs broke out in an epidemic of the monkeypox. It took a hard toll on the city of Tenochtitlan, and helped lead to their downfall.
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Cortes and his men arrived in the city of Tenochtitlan in 1519. They were recieved as honored guests, in accordance to Aztec custom.
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The Aztecs began to be conquered by Spain in 1521.
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The Aztec final surrender to Cortés was in the city of Cuauhtémoc. Cortés recieved many allies in his seize of their citites, as the Aztecs were not well liked.
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From 1545-1548 their was an outbreak of Mono for the Aztec people.
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In 1576-1581, another epidemic occured, this one being of Yellow Fever. Along with mono, yellow fever killed off 75% of the population of Mesoamerica.