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First Cases
Surgeon General John Rollo treats diabetic patient by dietary restriction. -
Studies Arise
Claude Bernard discovered that the liver stored glycogen and secreted a sugary substance into the blood; he assumed the substance caused diabetes. -
Studies cont.
Von Mering disproved Bernard's liver theory when he discovered that removal of the pancreas caused diabetes. -
Insulin is Discovered
the discovery of insulin took place in Canada by Frederick Banting; he performed an experiment where is extracted pancreas from a healthy dog and injected it into a dog with diabetes and not into another with diabetes. -
Human Experiment
the first human, a 14 year old boy, recieved Banting's and Charles Best's insulin which led to the injections being purified a week later. -
Insulin cont.
insulin is produced commercially as a fast acting soluble, leading to multiple injections being necessary for continued results. Also led to people developing a longer lasting insulin. -
Insulin cont.
insulin is crystallized by JJ Abel -
Investigations Improve
the investigation of diabetes improves with the immunoassay by Solomon Berson and Rosalind Yalow - concentrations can be consistently measured -
Investigations cont.
the first testng for recombinant DNA insulin is announced. -
Investigations cont.
first biosynthetic human insulin is introduced -
Modern Day
inhalable insulin is produced and given out to consumers.
