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The King and Queen sent him on second voyage in September 1493 with 17 ships.
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Upon returning to Hispaniola, the 39 men were killed. Columbus went to take gold from the people that killed his men and this led to fighting.
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Columbus sent 500 Taino back to Spain to work as slaves. Remaining Taino had to mine gold.
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50,000 Taino natives died due to starvation, suicide, disease, amputation and war.
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Columbus went back to Spain to justify his actions to the King and Queen, leaving his brother in charge.