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Period: 1347 to 1351
Black Death
In 1347 the ships returned to the shores of Sicily full of sailors infected by a mysterious disease that caused dark swellings or buboes in the armpits and groin.
this symptom led to the nickname Black Death
While these quarantine efforts helped deter the outbreak, in the end, the Black Death took up to
200 million lives in Eurasia -
Period: 1541 to 1549
Plague of Justinian
This plague struck the Bizantine empire, it was caused by a bacterium identified as Yersinia pestis. Commonly known as bubonic plague, a pathogen carried by rats and transferred to humans through fleas.
The plague caused 25 to 50 million deaths (around a quarter of the Earth's population at the time). -
Period: to
Spanish flu
In 1918 ther was a mass pandemic that infected 500 million worldwide, unlike the most diseases Spanish flu impacted young adults the hardest, half of those that died were between the ages of 20 and 40 and 99% were under the age of 65.
By the end of 1920 Spanish flu claimed the lives of 50 to 100 million victims.