Oral Thrush

Thrush is 1st Described:

400

The term "thrush" was 1st described in "Of the Epidemics," a part of Hippocrarte's Book of Greek Medicine in about 400 B.C.
"Thrush" refers to the resemblance of "white flecks" which is seen in certain types of Candidiasis; it also refers to the breast or flock of birds

A Fever Is Reported

Sep 10, 1665

Samuel Pepys' Diary reported: "A patient hath a fever, a thrush and a hiccup."

Invasive Form of Thrush:

Feb 13, 1771

Nils Rosen Von Rosenstein defined an invasive form of thrush.

Beauvaria Bassiana Discovered To Cause Thrush

May 30, 1835

Thrush Described By:

Aug 6, 1838

Also described by French pediatrician Francois Valleix

1st Documentation of Fungus Assoc. With Thrush

Oct 20, 1839

Laugenbeck 1st documented fungus associated with thrush but failed to make a direct connection

Candida Albicans Is Classified

Jul 20, 1847

Frech mycologist Charles Phillipe Robin classified fungus as Oidium Albicans to name the fugus causing thrush.
*Albicans means "to whiten"

Pepys' Perception Is Accepted:

Feb 10, 1900

Mycologists accepted Pepys' perception

Candida Albicans Is Described:

Feb 5, 1923

Candida Albicans (C. Albicans) was 1st described by botanist Christine Marie Berkhout

1st Antifungal agent Nystatin Is Discovered

Nov 8, 1949

1st Use of Amphotericin B

Mar 31, 1958

1st Antifungal Use of Anazole

Nov 6, 1967

Pfizer Started A Program To Find Agent To Improve Antifungal Medications

Nov 25, 1978

Fluconazole is FDA Approved

Dec 15, 1990

Caspofungin Is FDA Approved

Jan 2, 2002

Search Still Continues For Antifungals

Jan 1, 2013