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Leonardo is born on April 15 in the village of Anchiano, near the town of Vinci.
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At 15 Leonardo is sent to Florence to work as apprentice to Andrea De Verrocchio.
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20 year-old Leonardo is accepted into the painters' guild of Florence.
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Leonardo is accused of sodomy; he is publicly humiliated although the charges are later dropped.
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Leonardo begins work on The Adoration of the Magi, an altarpiece for the Monastery of San Donato at Scopeto.
He sketches many studies. -
Leonardo paints the Virgin of the Rocks.
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Leonardo begins work on The Last Supper in the refectory of the convent of Santa Maria delle Grazie in Milan.
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Leonardo begins painting the Virgin and Child with Saint Anne, a project that he only finishes after 10 years.
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Leonardo returns to Florence.
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Leonardo begins work as senior military architect and general engineer for Cesare Borgia, son of Pope Alexander VI.
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Leonardo is commissioned to paint the Mona Lisa.
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Leonardo is commission to paint a mural for the council hall in Florence's Palazzo Vecchio, which is to be the Battle of Anghiari, a work that would remain unfinished.
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Leonardo paints St. John the Baptist.