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Edward Jenner tested the hypothesis that infection with cowpox could protect a person from smallpox infection.
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Benjamin Waterhouse, a Harvard professor of medicine, performed the first U.S. vaccinations on his children
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Beginning in 1817, a series of deadly cholera pandemics swept over India, Asia, and the rest of the world.
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In 1820, the deaths from smallpox dropped to 7858, the had gone down in the last decade, from being 18447
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Pasteur produced the first laboratory-developed vaccine: the vaccine for chicken cholera.
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Pasteur began careful work on rabies, attempting to infect other animals with rabies and identify the site and cause of infection.
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The Anti-Vaccination League of America held its first meeting in New York. They believed that smallpox was spread through filth and not contagion. This became a popular, though incorrect, argument of anti-vaccinationists.
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Pasteur successfully prevented rabies in nine-year-old Joseph Meister by post-exposure vaccination.
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Spanish physician Jaime Ferrán developed a cholera vaccine. His vaccine was the first to immunize humans against a bacterial disease.
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English physician S. Monkton Copeman improved the vaccine
