History of Insulin

  • 1500

    Fed a cup of cooking oil

    Before insulin was discovered, this is how they treated it. Fail
  • Thomas Willis discovered the smell of urine of diabetics

  • John Rollo treated first patient with dietary restriction.

  • Claude Bernard discovered that the liver stored glycogen and secreted a sugary substance into the blood

  • Von Mering discovered Bernard's liver theory and that removing the pancreas caused diabetes

  • Fredrick Banting, Macloud, and Charles Best prepared an extract from the panaceas of a dog

  • First human patient receives insulin from Banting and Best

    Failed
  • Purified injections made

    Glucose levels dropped
  • Insulin was being produced commercially and use to treat diabetes

    Used in most Western countries
  • Insulin was crystallized by J.J.Abel

  • Protamine zinc introduced

    Longer acting
  • Lente insulins were introduced

  • Easier to measure small amounts of insulin - immunoassay