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“Antonine” plague kills 5 million people of the Roman empire (165-180). Emperors Lucius Verus (in 169) and Marcus Aurelius (in 180) also succumb to the plague.
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541: “Justinian plague” kills a quarter of the population in the Mediterranean region, & 25 million worldwide. At its peak, 5-10,000 deaths a day in Istanbul (then called Constantinople). Most likely bubonic plague.
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Cholera had been around for a long time in India, but it took the development of trade routes and travelers to help spread it worldwide. The first pandemic starts in India, and spreads to the Middle East, Russia and China. Mortality must have been extremely high, but exact numbers are not available. The British Army recorded 100,000 deaths just amongst its troops. There have been 7 cholera pandemics since then, with the latest one starting in 1961, and and continuing to the present.
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Extra extra: How epidemics shaped the modern metropolis. http://www.nytimes.com/2008/04/15/science/15chol.html
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