death of the head of the cartel of Medellin, Pablo Escobar. By Alexander Caicedo Dec 3, 1993 death of the head of the cartel of Medellin, Pablo Escobar. the 3 of december of 1993 the drug trafficker Pablo Escobar, head of the cartel of Medellin is slaughtered and assassinated in a house in Medellin.