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1492
Hispaniola
Columbus lands at Hispaniola in the Caribbean. -
1513
Panama
Balboa "discovers" the Pacific Ocean in Panama. -
1521
Tenochtitlan
Cortes conquers the Aztecs at Tenochtitlan (Mexico City). -
1539
Mississippi River
De Soto explores the region between Florida and the Mississippi River. -
Jamestown, Virginia
First permanent English settlement is founded in Jamestown, Virginia. -
Mayflower Pilgrims
Mayflower Pilgrims found Plymouth colony in Massachusetts. -
King Philip's War
English settlers defeat Native Americans in King Philip's War. -
Louisiana
France claims the Mississippi River Valley and names it Louisiana.