Aztec Invasion By kanders1986 Jul 1, 1519 Begining of Invasion of Mexico The Spanish invaded cuba. Nov 18, 1519 Cortes met the leader of the Aztec. Apr 18, 1520 Cortes leaves to confront Velazquez. Apr 22, 1520 Spanish massacre Aztec people Jun 1, 1520 Spanish try to escape Tenochtitlan. Oct 1, 1520 Aztecs struck by smallpox disease. Aug 13, 1521 Aztecs surrender. Jan 1, 1522 Cortes becomes governer.