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Smallpox arrives in Mexico
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Cabeza De Vaca journeys through Mexico, at and against his own will.
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Jaques Cartier explores the St. Lawrence river / Canada
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Hernando De Soto explores Southeast North America covering modern day Florida, Georgia, South Carolina, Tennessee, Alabama, Mississippi, Arkansas, and Texas. Creates animosity between Indigenous and Europeans. / US
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Typhus breaks out in Mexico
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Santa Elana colony founded / South Carolina
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Influenza and Smallpox breakout/ SA/Mexico
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1st and 2nd attempts at establishing the Roanoke Colony. / North Carolina
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Santa Elana Colony fails / South Carolina
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Samuel Champlain Explores the Atlantic coastline of northern North America
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The Virginia Company was granted a charter
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The Virginia Company attempts 1st colony effort at Jamestown / Virginia
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Samuel De Champlain founds Quebec/ New France
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Diphtheria break out / SA/Mexico
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Measles breakout/ SA/Mexico
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Puritans land in Plymouth. / New England
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Virginia Company's charter is revoked by King James, and Jamestown becomes a royal colony. / Virginia
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Dutch sign a treaty with the Pequot to allow trade at the House of Good Hope and allowed them to stay in the land of Hartford. / New England
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Jesuit Paul Le Jeune travels with Algonquins / Canada (New France)
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Englishman John Stone is killed by an band of Indigenous people after holding natives captive. / New England
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John Oldham killed by an Indigenous band, Puritans demand retribution from Pequot despite knowing their lack of involvement.
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Jean De Brebeuf spends an extended period of time with the Huron / New France
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Huron suffer a smallpox outbreak/ New France
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English Settlers from Mass. Bay and Connecticut Colony along with Indigenous allies go to war against the Pequot people. / New England
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Huron suffer a Flu outbreak/ New France
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Jean De Brebeuf and Huron Band killed by Iroquois. / Canada