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100
Summer 4000 BCE
"Sumerian artifacts depict opium poppy." -
102
Babylon 2250 BCE
"Babylonians relieve toothache with henbane (Hyoscyamus niger)." -
106
Acupuncture- 1600 BCE
"Acupuncture is being practiced in China, according to Shang Dynasty pictographs on bones and turtle shells." -
110
India 600 BCE
"India's Sushruta uses cannabis vapors to sedate surgical patients. Over ensuing centuries, other herbs like aconitum would supplement that sedation in India and eventually in China." -
120
Plato 350 BCE
"Plato refers to ANAIΣΘHΣIA in his work Timaeus." -
200
Hua Tuo (ca. 111 – 207 AD) wine and herbal mixture
"Hua Tuo performs surgery with his general anesthetic Mafeisan, a wine and herbal mixture." -
220
Cannabis is used by Hoatho
In 220 AD Hoatho, a Chinese surgeon recoded using Cannabis during his procedures. -
Feb 1, 1350
Incas 1350 AD
"Inca shamans chewed coca leaves mixed with vegetable ash and dripped their cocaine-laden saliva into the wounds of patients." -
Feb 20, 1525
Paracelsus- First to use ether on animals.
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Feb 1, 1540
Cordus synthesizes Ether
"German physician and botanist Valerius Cordus (1515–1544), synthesizes diethyl ether by distilling ethanol and sulphuric acid into what he called "sweet oil of vitriol." -
Mesmer's Hypnosis
"Franz Anton Mesmer (1734–1815)—In Mémoire sur la découverte du magnétisme animal, he describes using magnets and hypnosis to cure many ailments." -
Humphry Davy observes ether's ability to destroy pain
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William Clarke uses ether for dental extraction
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Crawford W. Long performs his painless surgery
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Opium sponges ca. 800 – ca. 1200s
"After herbal mixtures including opium, mandrake, henbane, and/or hemlock are steeped into a soporific or sleep-bearing sponge ("spongia somnifera"), the sponge is dampened so that anesthetic vapors or drippings can be applied to a patient's nostrils."
