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He leads an unsuccessful expedition to explore the area later known as Paraguay.
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He leads a Guaraní army of 200 across the Gran Chaco.
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He sails up the River Paraná and establishes a settlement known as Sancti Spiritu.
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He attempts to reach Sancti Spiritu, but fails at the banks of the River Plate. His second in command Juan de Ayolas sails up the River Paraguay and discovers Cabot's abandoned settlement. Domingo Martínez de Irala, another sailor, joins him and is appointed lieutenant to take charge of the region. Ayolas ventures into the Chaco and disappears.
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They sail upstream to meet Irala, who guides them to a safe port. A fort is constructed on the riverbank on August 15 and named Asunción for the Catholic feast day. It becomes an outpost for goods being shipped across the continent and later the colony's capital. Settlers are given the right to elect leaders of the colony.
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He modernizes Paraguay by introducing agriculture and local industry. He repairs relations with the natives.
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Jesuits start their work on establishing Jesuit reductions for native Guaranis in the Governorate of Paraguay.
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Timeline of Paraguayan history. (2020). Retrieved 11 February 2020, from https://en.wikipedia.org/wiki/Timeline_of_Paraguayan_history