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Paracetamol
Harmon Northrop Morse had already synthesized paracetamol at Johns Hopkins University via the reduction of p-nitrophenol with tin in glacial acetic acid in 1877 -
Antifebrin
Paracetamol was introduced into medical practice under the name of Antifebrin by A. Cahn and P. Hepp in 1886 -
Period: to
Paracetamol
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it was tested on patients
1887 that clinical pharmacologist Joseph von Mering tried paracetamol on patients. -
paracetamol
1893, von Mering published a paper reporting on the clinical results of paracetamol with phenacetin, another aniline derivative. -
phenacetin
1899, phenacetin was popular for many decades, particularly in widely advertised over-the-counter "headache mixtures", usually containing phenacetin, an aminopyrine derivative of aspirin, caffeine, and sometimes a barbiturate. -
methemoglobinemia.
1947 David Lester and Leon Greenberg found strong evidence that paracetamol was a major metabolite of acetanilide in human blood, and in a subsequent study they reported that large doses of paracetamol given to albino rats did not cause methemoglobinemia. -
Pharmacology
September 1948 issue of the Journal of Pharmacology and Experimental Therapeutics, Bernard Brodie, Julius Axelrod and Frederick Flinn confirmed using more specific methods that paracetamol was the major metabolite of acetanilide in human blood, and established that it was just as efficacious an analgesic as its precursor. -
The "rediscovery" of paracetamol.
A followup paper by Brodie and Axelrod in 1949 established that phenacetin was also metabolized to paracetamol.This led to a "rediscovery" of paracetamol. -
aspirin
Paracetamol was first marketed in the United States in 1953 by Sterling-Winthrop Co., which promoted it as preferable to aspirin since it was safe to take for children and people with ulcers.[ -
children could start taking aspirin
Paracetamol was first marketed in the United States in 1953 by Sterling-Winthrop Co., which promoted it as preferable to aspirin since it was safe to take for children and people with ulcers. -
para-acetylaminophenol
The best known brand today for paracetamol in the United States, Tylenol, was established in 1955 when McNeil Laboratories started selling paracetamol as a pain and fever reliever for children, under the brand name Tylenol Children's Elixir—the word "tylenol" was a contraction of para-acetylaminopheno -
Panadol
In 1956, 500 mg tablets of paracetamol went on sale in the United Kingdom under the trade name Panadol, produced by Frederick Stearns & Co, a subsidiary of Sterling Drug Inc. Panadol was originally available only by prescription, for the relief of pain and fever, and was advertised as being "gentle to the stomach," since other analgesic agents of the time contained aspirin, a known stomach irritant. -
Pharmacopoeia
In 1963, paracetamol was added to the British Pharmacopoeia, and has gained popularity since then as an analgesic agent with few side-effects and little interaction with other pharmaceutical agents. -
Drug
The U.S. patent on paracetamol has long expired, and generic versions of the drug are widely available under the Drug Price Competition and Patent Term Restoration Act of 1984, although certain Tylenol preparations were protected until 2007. -
acetaminophen
U.S. patent 6,126,967 filed September 3, 1998 was granted for "Extended release acetaminophen particles
