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Dispersed throughout Europe for over 200 years (540-750AD) this plague is believed to have killed 50% of the world's population!
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Thought to have started in central Asia and killed 75 million people (at least 50 million in Europe alone). The Black Death reputedly killed between 50 and 60 percent of Europe's total populastion of the time!
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These three killers swept the world with the movement of explorers and soldiers. Believed to have killed MILLIONS of indigenous people in Mexico, Brazil and Peru.
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The first major influenza epidemic occurred in Europe (spanning approximately four years) and is thought to have killed 20% of Europe's population!
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About 60 million people are thought to have died from smallpox throughout the eighteenth century in Europe - including 60% of children aged five years and under!
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Globally 40-50million people died of this disease shortly after World War I. (This was more than 2% of the world's total population)