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541
Plague of Justinian
Was the first recorded major outbreak of the first plague pandemic.
The disease afflicted the entire Mediterranean Basin, Europe, and the Near East, severely affecting the Sasanian Empire and the Byzantine Empire and especially the latter's capital, Constantinople.
The contagion arrived in Roman Egypt in 541, spread around the Mediterranean Sea until 544, and persisted in Northern Europe and the Arabian Peninsula, until 549. -
1346
The Bubonic Plague
The plague is considered the likely cause of the Black Death that swept through Asia, Europe, and Africa in the 14th century and killed an estimated 50 million people, including about 25% to 60% of the European population.
Bubonic plague is an infection of the lymphatic system, usually resulting from the bite of an infected flea -
The Spanish Flu
It was an exceptionally deadly global influenza pandemic caused by the H1N1 influenza virus. The pandemic broke out near the end of World War I, when wartime censors suppressed bad news in the belligerent countries to maintain morale, but newspapers freely reported the outbreak in neutral Spain, creating a false impression of Spain as the epicenter and leading to the "Spanish flu" misnomer, the earliest documented case was March 1918 in Kansas, United States. -
Covid-19
The COVID-19 pandemic, also known as the coronavirus pandemic.
The novel virus was first identified from an outbreak in Wuhan, China, in December 2019. Attempts to contain it there failed, allowing the virus to spread to other areas of China and later worldwide, As of 27 October 2022, the pandemic had caused more than 629 million cases and 6.58 million confirmed deaths, making it one of the deadliest in history.