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Hernando de Soto becomes the first European to reach Missouri.
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In this time, St. Louis gets founded, and becomes a city in Missouri.
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The Louisiana Purchase buys a lot of land, including Missouri.
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The New Madrid earthquake in the Bootheel happens, causing a lot of desruction in Missouri, and forming Reelfoot lake, in Tenessee.
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Missouri becomes the 24th state in the USA, thanks to its population.
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Pioneers begin to leave Missouri on the Oregon trail.
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The Pony Express is estableshed to bring mail from Calofornia to Missouri.
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Missouri becomes the first slave-holding state to end slavery.
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Susan Blow opens the first public kindergarden in the US in Missouri.
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St. Louis hosts the World's Fair.
