Insulin Evolution

By nicpotes

  • Dietary Restriction

    Dietary Restriction
    John Rollo, Surgeon-General treated diabetes with dietary restrictions.

  • Bernard's liver theory disproved

    Bernard's liver theory disproved
    Von Mering discovered removing the pancreas caused diabetes

  • Insulin Discovery

    Insulin Discovery
    Fredrick Banting prepared an extract made of an atrophied pancreas and gave it to one dog with diabetes and compared how he did to the control dog who had diabetes and got no extract. The dog with the extract lived three more weeks than the control dog who died after four days.

  • Human receives insulin

    Human receives insulin
    Banting and Best give 14-year old boy insulin, the first human to receive it

  • Purified Injections

    Purified Injections
    After the first insulin injection failed it was purified and administered again by Collip, which worked

  • Insulin Commercially produced

    Insulin Commercially produced
    Throughout the majority of western countries insulin was being commercially produced to treat diabetes

  • Protamine Zinc Insulin

    Protamine Zinc Insulin
    Result of impure insulin that caused abscess and pain

  • Lente insulins

    Lente insulins
    As a result of impure insulin that caused pain and abscesses

  • Crystallized Insulin

    Crystallized Insulin
    Made by J.J. Abel two chains of 51 amino acids connected by disulphide bridges. This was discovered by fredrick Sanger in 1955

  • Immunoassay

    Immunoassay
    Created by Solomon Berson and Rosalind Yalow, small concentrations of insulin can be measured