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Period: 8000 BCE to 3000 BCE
Neolithic Revolution
Emergence of agriculture leading to the first permanent settlements and beginning of civilization around great rivers, including the Nile, Tigris and Euphrates, Indus, and Yellow Rivers. Settlements led to diseases related to higher population numbers and the development of social classes and professions (including “medical” professions) -
3300 BCE
Otzi the Iceman
Time of the life of Otzi the Iceman, who was found in 1991 in the Otzai Alps. He is thought to have perhaps been a shaman, as he was found with fire starting materials, mushrooms that may have been used as a styptic or antibacterial, and tattoos that some argue indicate an early form of acupuncture. -
1600 BCE
Smith papyrus
Earliest medical papyrus. Contains descriptions of general cases, with each entry including title, examination, diagnosis, prognosis (including 'do not treat') and treatment -
1550 BCE
Ebers papyrus
Extensive record of Egyptian medical knowledge, including herbal, magical, and folk remedies. -
Period: 900 BCE to 323 BCE
Hellenic period
Healing linked to religion: oracles provided insights, Asclepius was the god of medicine - people could appeal to him or visit his temples to be cured or to learn more about the causes and treatments of their afflictions -
Period: 600 BCE to 500 BCE
Sushruta Samhita
Approximate date for composition of the Sushruta Samhita (estimated by some to be the 6th century BCE, generally agreed as sometime in the 1st millennium BCE). Foundational text of Ayurvedic medicine with a focus on surgery. -
Period: 460 BCE to 370 BCE
Hippocrates' lifetime
The lifetime of Hippocrates, foundational Greek physician. The Hippocratic writings generally date from around this time period; though associated with Hippocrates, they were written by multiple authors expressing multiple perspectives. Gave recommendations on living in harmony with nature, applying philosophy to individual cases, and using specific drugs when necessary. -
Period: 401 BCE to 310 BCE
Bian Que's lifetime
Lifetime of Bian Que, earliest recorded Chinese physician. He was a legendary healer and wrote the Bian Que Neijing. -
Period: 335 BCE to 280 BCE
Herophilus' lifetime
Lifetime of Herophilus, a Greek physician who studied in Alexandria. He was interested in anatomy and made many discoveries relating to human anatomy, doing so by breaking taboos against dissecting human bodies and performing vivisections. -
Period: 200 BCE to 100 BCE
Compendium of Caraka
Approximate date for the Compendium of Caraka, a foundational text of Ayurvedic medicine. -
Period: 200 BCE to 100 BCE
Huang Di Nei Jing
Approximate date for the composition of Huang Di Nei Jing, a foundational text in Chinese medicine. -
Period: 23 to 79
Pliny the Elder's lifetime
Lifetime of Pliny the Elder, influential Roman author and natural philosopher. His best-known work is his encyclopedic Natural History. -
Period: 129 to 210
Galen's lifetime
Lifetime of Galen, a Roman physician and philosopher. His work was based on the humoral system and primarily focused on digestion. He also explored anatomy, though only through animal dissections. -
Period: 700 to 800
Sowa Rigpa
Approximate time of the establishment of Sowa Rigpa, the traditional Tibetan system of medicine -
Period: 1000 to 1200
Rise of corporations
Beginning and proliferation of legal corporations in Europe. Many medical professions were incorporated, most commonly barber-surgeons, surgeons, and apothecaries. -
1025
Avicenna's Canon
Completion of Avicenna's Canon, a very comprehensive and influential record of Islamic medicine. -
1076
Establishment of Chinese imperial pharmacy service
Included the production of official guides to pharmacology and attempts to bring pharmacy in line with traditional principles, such as yin and yang. -
1088
Founding of University of Bologna
Founded as a student-run university by an organized student guild. -
1348
Black Death outbreak
Followed by outbreaks in 1363 and 1374. The Black Death ravaged Europe, resulting in a 30-45% general mortality rate and causing economic and social changes. -
1492
Publication of De Plinii et plurium aliorum medicorum in medicina erroribus
Niccolò Leoniceno published this first criticism of Pliny, pointing out errors in the Natural History. -
Period: 1493 to 1541
Paracelsus' lifetime
Lifetime of Paracelsus, influential Renaissance physician. He drew on chemistry and alchemy to develop new "cures" and specific medicines. -
Period: 1500 to
Paper becomes more common, new medical sources
In Europe, paper becomes common enough to be used generally, leading to new sources about ordinary practitioners and 'common' medicine. These sources include letters, medical notebooks and casebooks, and handbills, pamphlets, and advertisements. -
Period: 1519 to
Decimation of indigenous population in the Americas
By 1620 (101 years after Cortez's arrival in the Americas), the population of indigenous peoples in the Americas has dropped to only 1/20 or 1/25 of the original pre-contact population. -
1543
Publication of De fabrica humani corporis
Andreas Vesalius publishes De fabrica humani corporis, a detailed piece on human anatomy including anatomical illustrations. This work corrected many mistakes in common (Galenic) conceptions of anatomy. -
1562
Publication of Coloquios dos simples e droga da India
Portuguese physician and naturalist Garcia da Orta publishes Coloquios dos simples e droga da India (Colloquies on the simples and drugs of India). This work introduced Europeans to many 'new' simples, including china root, opium, ginseng, and hashish. -
Publication of Bencao Gangmu
Publication of Bencao Gangmu, or Compendium of Materia Medica, by Li Shishen. This is a comprehensive record of 1,892 simples used in Chinese medicine. -
Period: to
Institutionalization of midwifery
Printed records, including contracts between midwives and a few works by women authors, date to this period. Institutionalization occurs as midwives' guilds are formed and as male midwives gain prominence due to increased state concern around fertility. -
Period: to
Rise of the medical marketplace
Emergence of the medical marketplace and the proliferation of patent medicines. -
Period: to
Sylvius' lifetime
Lifetime of Sylvius, Dutch physician and scientist who championed materialism in chemistry. -
Publication of De motu cordis et sanguinis
William Harvey published De motu cordis et sanguinis, establishing the circulation of the blood. -
Publication of De medicina Indorum
Posthumous publication of De medicina Indorum, a collection of Jacobus Bontius' observations relating to tropical medicine.