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  • 1434

    1434

    The Medici family becomes the head of the city-state of Florence.
  • 1450

    .

    Johannes Gutenberg invents the printing press.
  • 1453

    1453

    The Ottoman Empire captures the city of Constantinople, signaling an end to the Byzantine Empire.
  • 1485

    1485

    Henry VII becomes king of England beginning the reign of the House of Tudor.
  • 1492

    1492

    Explorer Christopher Columbus discovers the Americas.
  • 1501

    1501

    Michelangelo begins his work on the sculpture David.
  • 1516

    1516

    Sir Thomas More publishes his work Utopia on political philosophy.
  • 1517

    1517

    Martin Luther posts his 95 theses on the door of the Church of Wittenberg. This signals the start of the Reformation.