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premire date
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Addison Montgomery
Addison Montgomery (Kate Walsh) is introduced as a guest in season 1. -
Callie Torres
Callie Torres (Sara Ramirez) is first introduced in season 2. -
Mark&Erica
Mark Sloan (Eric Dane) and Erica Hahn (Brooke Smith) are first introduced as guest in season 2. -
Mark&Callie
Mark Sloan and Callie Torres (Eric Dane&Sara Ramirez) are made main characters in season 3. -
Lexie Grey
Lexie Grey (Chyler Leigh) is introduced as a guest in sason 3. -
Prseton&Addison
Preston Burke (Isaiah Washington) and Addison Montgomery (Kate Walsh) leave during season 3 but do appear as guest in later seasons. -
Owen&Arizona
Owen Hunt (Kevin McKidd) and Arizona Robbins (Jessica Capshaw) first appear in season 5. -
Erica Hahn
Erica Hahn (Brooke Smith) leaves the show in season 5. -
George O'Malley
George O'Malley (T. R. Knight) leaves the show in season 5. -
Teddy, Jackson, April, and Benjamin
Teddy Altman (Kim Raver), Jackson Avery (Jesse Williams), April Kepner (Sarah Drew), and Benjamin Warren (Jason George) are all introduced to the show in season 6. -
Izzy Stevens
Izzy Stevens (Katherine Heigl) leavs the show in season 6. -
Addison, Teddy, Lexie
Addison Montgomery, Teddy Altman, and Lexie Grey all leave the show in season 8. -
Mark Sloan
Mark Sloan (Eric Dane) leaves the show in season 9. -
Jo, Stephanie, Shane, and Leah
Jo Wilson (Camilla Luddington), Stephanie Edwards (Jerrika Hinton), Shane Ross (Gaius Charles), and Leah Murphy (Tessa Ferrer) join the show in season 9. -
Christina Yang
Christina Yang (Sandra Oh) leavs the show in season 10. -
Shane and Leah
Shane Ross (Gaius Charles) and Leah Murphey (Tessa Ferrer) lave the show in season 10. -
Derek Shepherd
Derek Shepherd (Patrick Dempsey) leaves the show in season 11.
