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1980
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FK506 isolation
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Total synthesis by Merck
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Formal synthesis by Sih et al
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Formal synthesis by Danishefsky et al
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Total synthesis by Schreiber et al
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First US Patent held by Merck
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FK506 made industrially using 22nd generation bacteria
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FDA approval for liver transplants
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Formal total synthesis by Smith et al
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Total synthesis by Ireland et al
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Biosynthetic gene clusters identified
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Total synthesis by Ireland et al
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Formal synthesis routes proposed by Smith et al
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International Patent under Lek Pharmaceuticals
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2015