Famous Female Firsts in U.S. History By jbon311 Jul 8, 1848 First Women's Rights Convention Seneca Falls, NY Seneca Falls, NY Mar 8, 1849 Elizabeth Blackwell first woman in U.S. with a medical degree Changing the Face of Medicine Mar 8, 1916 Jeannette Rankin first woman in Congress Women in Congress Oct 8, 1916 Margaret Sanger opens first birth control clinic Mar 8, 1921 Edith Wharton first woman to win a Pulitzer Prize Edith Wharton Jun 17, 1928 Amelia Earhart first woman to cross the Atlantic in an airplane Amelia Earhart Mar 8, 1943 All American Girls Professional Baseball League AAGPBL Mar 8, 1978 Janet Guthrie first woman to drive in Indy 500 Janet Guthrie Jul 7, 1981 Sandra Day O'Connor first U.S. Supreme Court Justice Justice O'Connor Jun 18, 1983 Sally K. Ride first American woman in space Sally K. Ride biography Jan 23, 1997 Madeleine Albright first female Secretary of State Albright Mar 8, 2010 Kathryn Bigelow first female to win Oscar for Best Director Oscar