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Azathioprine, the first immunosuppression drug, is used to prevent rejection of transplanted organs.
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First successful kidney transplant from a deceased organ donor.
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First organ recovered from a brain-dead donor.
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Tissue antigen (HLA type) matching between donors and recipients reported as the standard to achieve the best deceased donor kidney transplant outcomes.
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First successful pancreas transplant performed (along with a kidney transplant).
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Antilymphocyte serum introduced to extend organ survival in kidney (1966) and liver (1967) transplants. This drug helped prevent the rejection of transplanted organs.
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First successful liver transplant performed.
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Paul Terasaki reported on the crossmatch test for kidney transplants between donors and recipients; started first organ sharing organization in Los Angeles.
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The first successful heart transplant from a donor after cardiac death (DCD) was performed.
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First definition of “brain death” based on clinical neurological criteria became the basis for “brain death” laws in all 50 states.
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The first organ procurement organization (OPO), New England Organ Bank, was established. It was the first entity dedicated solely to identifying deceased donors in the local area.
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Uniform Anatomical Gift Act (UAGA) established the first Uniform Donor Card as a legal document of gift in all 50 states. The UAGA also identified who could donate a deceased person's organs, and allowed people over 18 to donate their organs upon death.
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First successful lung transplant performed.
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UDDA defines death as the irreversible loss of blood flow and breathing or irreversible loss of all brain activity and functions.
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First combined heart/bilateral lung transplant performed.
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First successful single-lung transplant performed.
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The Food and Drug Administration approved cyclosporine (discovered in 1976). This drug reduces the potential for organ rejection
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The National Organ Transplant Act (PL 98-507) was established. This law made it illegal to sell human organs.
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Required Request law. Allowed families the chance to donate deceased family members organs.
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The first OPTN contract is awarded by the U.S. Department of Health and Human Services to the United Network for Organ Sharing.
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First successful intestine transplant performed.
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First successful split-liver transplant performed.
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FDA approves Belzer University of Wisconsin’s organ preservation solution, allowing organs to be in cold storage for almost double the time.
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First successful living donor liver transplant performed.
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First successful living donor lung transplant performed.
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The first kidney paired donation (KPD) exchange transplant performed.
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First living donor kidney removed by laparoscopic surgery.
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The Centers for Medicare & Medicaid Services (CMS) issued Hospital Conditions of Participation in Medicare and Medicaid programs. This requires hospitals to refer all deaths and approaching deaths to the local organ procurement organization.
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First successful hand transplant performed.
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Children’s Health Act (PL 106-310)changed the National Organ Transplant Act to require the OPTN to adopt criteria and policies that address children’s unique needs.
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First successful partial face transplant performed.
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First successful full face transplant performed.
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The first live birth after uterus transplantation from a living donor occurred.
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First HIV-Positive to HIV-Positive kidney transplant.
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First live birth after uterus transplantation from a deceased donor occurred.
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First organ transport and delivery by drone.
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The first COVID-19 patient receives a double lung transplant.
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