Aztec By raaayyyna May 13, 1325 Aztecs arive in valley of mexico Dec 17, 1325 tenochtitlan is established Apr 17, 1492 king ferdinand and queen isabella treaty of capture granada tortestilla Apr 17, 1494 treaty of tortesillas Jun 22, 1502 Moctezuma becomes leader of the Aztecs Jul 13, 1519 Cortes arives in mexico Aug 28, 1520 moctezuma killed, spanish driven out of Tenochtitlan smallpoxs outbreak among Aztecs Apr 9, 1521 Spanish defeat Aztecs Apr 17, 1531 inca empire invaded pizarro Oct 16, 1821 Mexico gains independance from spain