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350
aristotle
Aristotle came up with the method of gathering scientific facts, which proved as the basis for all scientific work -
400
Democritus
Democritus said that all matter is made up of particles called "atomos". He also stated that atoms are eternal and invisible and so small that they can’t be divided, and they entirely fill up the space they’re in. -
Antoine Lavoisier
Antoine Lavoisier formulated the law of conservation of mass, which is that the total mass in a chemical reaction remains constant. He also distinguished between an element and a compound.