Timeline of evolution of ophthalmological imaging techniques By JPSt 1569 Camera Obscura Concept by Daniele Barbaro 1726 First Attempt at Permanent Image Capture by Johann Schultz 1822 Technique for Ophthalmoscopy Described by Jan Purkinje 1824 First Photograph by Nicéphore Niépce Period: 1829 to 1839 Development of Ophthalmoscope 1850 Invention of Direct Ophthalmoscope by Hermann von Helmholtz 1871 Synthesis of Fluorescein Dye by Adolf von Bäyer 1886 First Photography of Human Fundus In Vivo 1925 Development of Fundus Camera by J.W. Nordenson 1930 Invention of Stroboscopic Flash by Harold Edgerton 1953 Coupling of Electronic Flash with Fundus Camera 1957 Patent of Confocal Microscopy by Marvin Minsky 1961 Description of Fluorescein Angiography 1975 Invention of Digital Camera by Steven Sasson 1979 Invention of Scanning Laser Ophthalmoscopy 1987 Introduction of Digital Photography in Fundus Camera 1991 Description of Optical Coherence Tomography (OCT) 1992 Development of Angiographer Using cSLO 1995 Introduction of Image Management Software by Microsoft 2007 Introduction of Spectral is HRA + OCT 2008 Introduction of Handheld OCT Devices 2010 Introduction of Swept-Source OCT Technology 2014 Development of OCT Angiography (OCTA) 2016 Introduction of Artificial Intelligence in Ophthalmology Imaging 2020 Integration of AI for Image Analysis and Diagnosis 2024 Ongoing advancements in ultra-high-resolution and integration with other imaging modalities in ophthalmic diagnostics