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March 4, 1861, seven cotton states declared their secession and joined to form the Confederate States of America.
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Hostilities began on April 12, 1861, when Confederate forces attacked a U.S. military installation at Fort Sumter
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In September 1862, the Confederate campaign in Maryland ended in defeat at the Battle of Antietam
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In 1863, Confederate general Robert E. Lee's northward advance ended in defeat at the Battle of Gettysburg
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Ulysses S. Grant was given command of the eastern army in 1864, and organized the armies of William Tecumseh Sherman, Philip Sheridan and others to attack the Confederacy from all directions, increasing the North's advantage in manpower.
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Confederate attempt to defend Petersburg failed, the Confederate army retreated but was pursued and defeated. Lee's surrender to Grant happened at Appomattox Court House on April 9, 1865.