-
Period: 165 to 185
Antonine Plague
Death toll 5–10 million -
Period: 541 to 549
Plague of Justinian
Death toll 15–100 million -
Period: 1346 to 1353
Black Death
Death toll 75–200 million -
Period: 1519 to 1520
1520 Mexico smallpox epidemic
Death toll 5–8 million -
Period: 1545 to 1548
Cocoliztli epidemic of 1545–1548
Death toll 5–15 million -
Period: to
Third plague pandemic
Death toll 12–15 million -
Period: to
Spanish flu
Death toll 17–100 million -
Period: to
1918–1922 Russia typhus epidemic
Death toll 2–3 million -
Period: to
1957–1958 influenza pandemic
Death toll 1–4 million -
Period: to
HIV/AIDS global epidemic
Death toll 36.3 million (as of 2020) -
Period: to
COVID-19 pandemic
Death toll 5–19 million (as of 24 October 2021)