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Samual Clemens is born
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Clemens Family moves to Hannibal, Missouri
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John Clemens, Mark Twain's father, dies
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Twain begins work as printer for Hannibal Gazette
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Begins apprenticeship as steamboat pilot
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Henry Clemens, Twain's youngest brother, dies in steamboat explosion, leaving Twain feeling guilty for encouraging Henry to become a boat pilot
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Civil War breaks out, ending Twain's steamboat career
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Twain travels to Nevada with brother Orion and eventually becomes reporter for the Virginia City Daily Territorial Enterprise
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Twain travels to California, passing through Calaveras County before settling in San Francisco
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"The Celebrated Jumping Frog of Calaveras County" is published in the New York Saturday Press
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Twain gives his first public lecture, and it's very well-received
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Twain meets his future wife, Olivia Langdon, the sister of a friend, and falls head-over-heels
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Twain's first book, The Innocent Abroad, is published and goes on to become a best-seller
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Twain marries Olivia Langdon, and their first son, Langdon, is born
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Twain and family move to Connecticut, where their daughter is born, but their son dies of diptheria
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Twain's second book, The Gilded Age, is published, and his very successful self-pasting scrabook comes out as well
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Twain's second daughter and third child is born
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The Adventures of Tom Sawyer is published
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Twain's third daughter and fourth, and final, child is born
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Twain's memoir of hi time as a steamboat pilot, Life on the Mississippi, is published
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Twain founds his own publishing company, , Charles L. Webster & Co, named after his nephew and co-owner
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Mark Twain's greatest fiction and non-fiction accomplishments are published, The Adventures of Huckleberry Finn, and a biography of President Ulysses S. Grant
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Twain publishes A Connecticut Yankee in King Arthur's Court, which gets slammed by the critics
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Twain moves to Europe for cheaper living after poor decisions leave him and his family in poverty
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Twain's last novel, Pudd'nhead Wilson, is published, and his finances all but crumble
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Twain goes on a lecture tour to pay back the money he owes
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Twain's oldest daughter dies of meningitis, devastating Twain and essentially ending his successful writing career
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Twain's wife loses her battle with a two-year illness, prompting Twain to move to New York and begin his autobiography
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Twain's youngest daughter is institutionalized for her severe epilepsy, and his bigrapher moves in with him to collect material
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Twain, missing his wife and daughters, forms the Angelfish Club, a group of young girls that meet at his house regularly to play cards
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Twain's youngest daughter dies
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Mark Twain dies at age 74 in his home in Connecticut