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527
Justinian became leader of Byzantine Empire
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532
The Hagia Sophia was destroyed.
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542
The worst of the plague. 10,000 poeple died daily.
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565
Justinian died.
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Dec 13, 626
Persians and Avars struck against Constantinople
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Jan 21, 1043
Attacked many times by Russians and Turks took over Muslim world.
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Dec 13, 1453
City fell to Ottoman Turks.
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Justinians wife died.
