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541
Plague breaks out in the eastern Roman Empire killing some 10 000 people daily in Constantipole it largely died out by 750
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1333
Plague breaks out in north-eastern China, killing five million people that year
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1346
Plague reaches The Crimea
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1347
Plague Spreads in Cyprus, Italy and Egypt
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1348
Plague reaches Paris, England, Belgium, Netherlands, Cairo and Gaza
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1349
Widespread persecution of Jews, with thousands burned to death plague reaches Aswan in Egypt and the entire Islamic world is now effected
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1350
Plague has largely run its course in the Mediterranean basin
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1351
Plague reaches Russia
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1353
Some 35 million deaths from the plague recorded in China since 1333