Ancient Mesopotamia By Kennadii_ 5000 BCE The first sumerians move in and begin farming 3700 BCE The first town, Uruk appears 3100 BCE Cuneiform script develops 2330 BCE Sumer and Akkad falls, the Babylonians take over 1770 BCE The use of the wheel and horses revolutionizes warfare and trasnsport 1365 BCE Assyrian Empire defeats the Babylonians, flourishesand takes control over some partsof Indus Valley and Egypt 620 BCE Assyrian Empire crumbles Onc epowerful ruler Ashurbanipal dies, the strong Assyrian Empire crumbles. The Babylonians took this opportunity to once again take control 539 BCE Persian ruler, Cyrus the Great storms in and takes over mesopotamia 334 BCE Alexander the great invades and conquers mesopotamia