Top 10 Deadliest U.S. Hurricanes from 1851-2006 By mlmoran89 Aug 10, 1856 No 9. Last Island Category 4. Estimated 400 deaths. More info Aug 27, 1881 No. 6 Georgia/South Carolina Category 2. Estimated 700 deaths. Aug 27, 1893 No. 5 Sea Islands, SC/GA Category 3. Estimated 1,000 to 2,000 deaths. More info Oct 1, 1893 No. 4 Cheniere Caminada, LA Category 4. Estimated 1,100 to 1,400 deaths. More Info Sep 8, 1900 No. 1 Galveston, TX Category 4. Estimated 8,000 deaths. More Info Interactive Map Sep 20, 1926 No. 10 Great Miami Category 4. Estimated 372 deaths. More Info Interactive Map Sep 6, 1928 No. 2 San Felipe-Okeechobee Category 4. Estimated 2,500 deaths. More Info Interactive Map Sep 2, 1935 No. 8 Florida Keys Category 5. Estimated deaths 408. More Info Interactive Map Jun 28, 1957 No. 7 Audrey Category 4. Estimated 416 deaths. More Info Interactive Map Aug 23, 2005 No. 3 Katrina Category 3. Estimated 1,500 deaths. More Info Interactive Map