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The Great War
The Great War begins and ends, lasting only 2 hours. Most of the planet is razed to the ground from the nuclear weapons used. -
The Brotherhood of Steel is founded.
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Psychoactive drugs are released to the residents of Vault 106.
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The residents of Vault 87 are transformed into super mutants as part of an experiment by Vault-Tec.
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Little Lamplight, the city of children is founded
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Vault 111 is allowed to be opened, but the overseer refuses to open it, causing a mutiny.
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Ambassadors from Vault 94 leave the vault to find and help survivors.
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Vault 77's social experiment begins with its sole resident opening the crate of puppets.
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The resident of Vault 77 leaves into the wasteland.
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Radiation effects become more prominent with the mutations of humans and animals.
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Sierra Army Depot VI's AI, Skynet, becomes self-aware
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The Brotherhood of Steel begins focusing on getting supplies from the neighboring factions.
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Vault 95's experiment by Vault-Tec begins.
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The city of Necropolis is founded by ghoul survivors.
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The Brotherhood of Steel creates an outpost at Big Bend Tunnel.
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Vault 29 opens releasing Harold to become a trader.
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Vault 8 opens and Vault City is founded
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The Los Angeles Vault opens and the Boneyard is founded.
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The Hub is founded by Angus.
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The residents of Vault 22 leave the vault due to an outbreak of mutated spores.
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Vault 15 opens.