ACS P2Y12i pretreatment

By peterhcs

  • CURE, NEJM 2001, Clopidogrel: the first concept of pretreatment

    Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE study
    Lancet, 358 (2001), pp. 527-533
    => Clopidogrel pretx vs no pretx: pretx better
    *but this trial mean time to PCI = 10 days, much longer than current practice

  • CREDO: RCT, JAMA 2002; Clopidogrel

    Steinhubl SR, Berger PB, Mann JT III, et al. Early and sustained dual
    oral antiplatelet therapy following percutaneous coronary interven-
    tion: a randomized controlled trial. Jama. 2002;288(19):2411–2420.

  • TRITON-TIMI 38: RCT, NEJM 2007, Prasugrel vs Clopidogrel

    Prasugrel versus Clopidogrel in Patients with Acute Coronary Syndromes
    N Engl J Med 2007; 357:2001-2015
    DOI: 10.1056/NEJMoa0706482
    => NSTEACS: all pt were not pretreated

  • ACCOAST: NEJM 2013 Prasugrel

    Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. N Engl J Med. 2013 Sep 12;369(11):999-1010. doi: 10.1056/NEJMoa1308075. Epub 2013 Sep 1. PMID: 23991622.
    => Prasugrel pretx: increase in major bleeding
    *time from loading dose to CAG: median 4h (shorter than real world condition)

  • ARIAM-Andalucia: Obs, AJC 2015

    Prognostic impact of clopidogrel pretreatment in patients with acute coronary syndrome managed invasively. Am J Cardiol. 2015 Apr 15;115(8):1019-26. doi: 10.1016/j.amjcard.2015.01.531. Epub 2015 Jan 31. PMID: 25728644.

  • NCVD Data Registry JAHA 2017

    Precatheterization Use of P2Y12 Inhibitors in Non-ST-Elevation Myocardial Infarction Patients Undergoing Early Cardiac Catheterization and In-Hospital Coronary Artery Bypass Grafting: Insights From the National Cardiovascular Data Registry®. J Am Heart Assoc. 2017 Sep 22;6(9):e006508. doi: 10.1161/JAHA.117.006508. PMID: 28939715; PMCID: PMC5634296.

  • ISAR-REACT 5: RCT, NEJM 2019

    Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes.
    N Engl J Med. 2019 Oct 17;381(16):1524-1534. doi: 10.1056/NEJMoa1908973. PMID: 31475799.

  • EARLY: RCT, JACC Interv 2020

    Optimal Timing of Intervention in NSTE-ACS Without Pre-Treatment: The EARLY Randomized Trial. JACC Cardiovasc Interv. 2020 Apr 27;13(8):907-917. doi: 10.1016/j.jcin.2020.01.231. PMID: 32327087.

  • DUBIUS: RCT, JACC 2020

    Timing of Oral P2Y12 Inhibitor Administration in Patients With Non-ST-Segment Elevation Acute Coronary Syndrome. J Am Coll Cardiol. 2020

  • SCAAR: Swedish, obs study, JAMA NO 2020

    Association of Pretreatment With P2Y12 Receptor Antagonists Preceding Percutaneous Coronary Intervention in Non-ST-Segment Elevation Acute Coronary Syndromes With Outcomes. JAMA Netw Open. 2020 Oct 1;3(10):e2018735. doi: 10.1001/jamanetworkopen.2020.18735. PMID: 33001202; PMCID: PMC7530628.